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TME Pharma AG
TME Pharma is a clinical-stage company focused on developing novel therapies for treatment of the most aggressive cancers. The company’s oncology-focused pipeline is designed to act on the tumor microenvironment (TME) and the cancer immunity cycle by breaking tumor protection barriers against the immune system and blocking tumor repair. By neutralizing chemokines in the TME, TME Pharma’s approach works in combination with other forms of treatment to weaken tumor defenses and enable greater therapeutic impact. In the GLORIA clinical trial, TME Pharma is studying its lead drug candidate NOX-A12 in newly diagnosed brain cancer patients who will not benefit clinically from standard chemotherapy. TME Pharma has delivered top-line data from the NOX-A12 three dose-escalation cohorts combined with radiotherapy of the GLORIA clinical trial, observing consistent tumor reductions and objective tumor responses. Additionally, GLORIA expansion arms evaluate safety and efficacy of NOX-A12 in other combinations where the interim results from the triple combination of NOX-A12, radiotherapy and bevacizumab suggest even deeper and more durable responses. NOX-A12 in combination with radiotherapy has received orphan drug designation for glioblastoma in the United States and glioma in Europe. TME Pharma has delivered final top-line data with encouraging overall survival and safety profile from its NOX-A12 combination trial with Keytruda® in metastatic colorectal and pancreatic cancer patients, which was published in the Journal for ImmunoTherapy of Cancer in October 2021. The company has entered in its second collaboration with MSD/Merck for its Phase 2 study, OPTIMUS, to further evaluate safety and efficacy of NOX-A12 in combination with Merck’s Keytruda® and two different chemotherapy regimens as second-line therapy in patients with metastatic pancreatic cancer. The design of the trial is in discussion with regulatory authorities in the United States and Europe. The company’s second clinical-stage drug candidate, NOX-E36, is designed to target the innate immune system. TME Pharma is considering several solid tumors for further clinical development. *
Start | 2022-07-15 renamed | |
Group | TME Pharma (Group) | |
Predecessor | Noxxon Pharma AG | |
Industry | drug development technology | |
Industry 2 | Spiegelmer® technology | |
Person | Mangasarian, Aram (Noxxon 201005 CBO before Novexel since 200511 VP BusDev before ExonHit VP BusDev) | |
Person 2 | Buchanan, Iain (Noxxon 201009– interim CEO before Novexel CEO before Vertex Pharmaceuticals) | |
Region | Berlin | |
Country | Germany | |
Street | 8-10 Max-Dohrn-Str. | |
City | 10589 Berlin | |
Tel | +49-30-726247-0 | |
Address record changed: 2024-01-05 | ||
Basic data | Employees | C: 51 to 100 (2011-09-06) |
Currency | EUR | |
Cash | 1,800,000 (2016-06-30) | |
* Document for »About Section«: Apogee Therapeutics, LLC. (12/7/22). "Press Release: Apogee Therapeutics Launches with $169 Million to Develop Potentially Best-in-Class Therapies for Immunological and Inflammatory Disorders". San Francisco, CA. | ||
Record changed: 2023-12-30 |
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More documents for TME Pharma (Group)
- [1] TME Pharma N.V.. (1/23/23). "Press Release: TME Pharma Provides Clinical Update on the GLORIA Expansion Arm Testing NOX-A12 in Combination with Radiotherapy and Bevacizumab in Patients with Glioblastoma". Berlin....
- [2] Noxxon Pharma N.V.. (1/3/22). "Press Release: Noxxon Secures €17 Million Expansion of Equity-linked Facility with Atlas to Advance NOX-A12 in Glioblastoma and Pancreatic Cancer Programs [ corrected version of press release originally issued 29 Dec 2021 ...
- [3] Noxxon Pharma N.V.. (10/27/21). "Press Release: Experienced Financial Executive, Bryan Jennings, Joins Noxxon as CFO". Berlin....
- [4] Noxxon Pharma N.V.. (12/14/18). "Press Release: Noxxon Announces Key Findings that NOX-A12 plus Keytruda Induces an Immune Response and Results in Clinical Benefit for Patients". Berlin....
- [5] Noxxon Pharma N.V.. (11/16/18). "Press Release: Noxxon Announces € 6.2 Million Equity Capital Raise including US$ 5 Million from US Family Office – Acuitas Capital, LLC. Noxxon Ends the Use of Variable Rate Equity Financing with Yorkville". Berlin....
- [6] Noxxon Pharma N.V.. (10/23/18). "Press Release: Noxxon to Attend European Investor and Partnering Conferences in November 2018". Berlin....
- [7] Noxxon Pharma N.V.. (6/15/18). "Press Release: Noxxon Announces that It Has Secured Additional Financing". Berlin....
- [8] Noxxon Pharma N.V.. (10/3/17). "Press Release: Noxxon Publishes Preclinical Proof-of-Concept Data for Lead Compound NOX-A12 in Combination with Checkpoint Inhibitors". Berlin....
- [9] Noxxon Pharma N.V.. (9/29/17). "Press Release: Noxxon Supervisory Board Elects Experienced US & EU Biotech Veteran Don deBethizy Chairman". Berlin....
- [10] Noxxon Pharma N.V.. (9/28/17). "Press Release: Noxxon Provides Update on Ongoing Phase 1/2 Clinical Trial with Lead Program NOX-A12". Berlin....
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