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UMC Utrecht. (4/30/15). "Press Release: Horizon 2020 Grant to Bart van der Worp".

Region Region Utrecht
  Country Netherlands
Organisations Organisation University Medical Center Utrecht (UMC Utrecht)
  Group University of Utrecht (Utrecht University)
  Organisation 2 PRECIOUS project (EU, FP8, 201506–202006, PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke)
Products Product clinical research
  Product 2 neurology
Index term Index term PRECIOUS project–EU (govt): grant, 201506–202006 Horizon 2020 grant €6m = total project cost co-ordinated by UMC Utrecht

This April, the European commission has awarded an Horizon 2020 grant sized almost € 6 million to the project PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. The project will be coordinated by neurologist Bart van der Worp and includes a pragmatic, randomised, clinical trial in 3800 elderly patients with acute stroke. Elderly patients are at high risk of complications after stroke, such as infections, fever, and dysphagia. These complications are strongly and independently associated with a higher risk of death or long-term dependency.

PRECIOUS will assess whether pharmacological prevention of infections and fever, and early management of dysphagia, will reduce the risk of death, poor functional outcome, and poor quality of life, and lead to reductions in the costs of stroke care throughout Europe. Patients will be enrolled in 80 centres in 9 European countries and randomised using a factorial design to preventive treatment for 4 days with ceftriaxone, paracetamol, and/or metoclopramide, or to ‘standard care’ alone. The primary outcome measure is functional outcome at 3 months.

The simple, safe, and generally available treatment strategies tested in PRECIOUS have the potential to lead to an annual reduction of over 25 000 elderly Europeans being dead or dependent as a result of stroke, at very low costs.

Record changed: 2019-04-26


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