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UCB S.A.. (2/11/19). "Press Release: UCB and Epilepsy Society Announce Pioneering UK Genomics R&D collaboration". Slough & Brussels.
Region | United Kingdom (GB) | |
Organisation | UCB S.A. (Euronext: UCB) | |
Group | UCB (Group) | |
Organisation 2 | Epilepsy Society (GB) | |
Product | pharmaceutical | |
Product 2 | antiepileptic drug | |
Person | Patel, Dhavalkumar (Dhaval) (UCB 201802 CSO) | |
> Five year, €2.5 Million R&D collaboration seeks to advance our current disease understanding and aims to progress treatment options by harnessing cutting edge science and data analysis to address a significant unmet need for patients living with epilepsy who do not respond to currently available medicines.
> Collaboration aligns with NHS England’s 10 Year Plan, aiming to be the first national health care system to offer whole genome sequencing as part of routine care.
> Collaboration launches on 11 February 2019 to coincide with International Epilepsy Day.
The Epilepsy Society and UCB, a global biopharmaceutical company headquartered in Belgium, with a significant UK R&D hub in Slough, UK, have today announced an exciting new collaboration to progress understanding of the genetic components of epilepsy, treatment responses and the impact on patient experiences through pioneering whole genome sequencing.
The hope is that research could ultimately result in improved and better targeted treatments for people with epilepsy which, in turn, could enable them to live their lives to the full.
With a specific focus on people who do not respond to currently available epilepsy medicines, the two organisations, who, in the UK, are located within 10 miles from each other in the South East of England, will work collaboratively over the next five years to develop an improved and deeper understanding of the complex nature of epilepsy, leveraging the recent technological advances in the field, such as genome sequencing, machine learning approaches and analysis of genetic biomarkers.
The first phases of the collaboration will focus on generating and analysing individual categories of data that have a role in determining a potential drug response, with an initial focus on the role of genetics. In the latter phases, the emphasis will move towards integrating different types of data sets and understanding how they act together. In this way, it is hoped to build a more complete picture of the drivers of treatment resistance in epilepsy, which will allow the exploration of ways to predict and treat it.
The long-term aim of the collaboration will be to use key insights from the research to design and develop improved, personalised approaches to the management of epilepsy, tailored to specific patient needs and genetic characteristics.
Professor Sanjay Sisodiya, Professor of Neurology at UCL and the Epilepsy Society's Director of Genomics, who is leading the research partnership within the charity said, “Advances in genomics present exciting potential for a paradigm shift in epilepsy. We hope to use them to gain a much better understanding of the disease trajectory, improving diagnosis and treatment for people living with epilepsy. Our hope is that by embracing genomics we will be able to provide personalised care for patients, eventually helping us to identify the right treatment, first time.”
What makes the Epilepsy Society/UCB collaboration unique is the detailed clinical data that it is able to harness. Epilepsy Society's Chalfont Centre in Buckinghamshire provides tertiary care for people with the most severe and uncontrolled epilepsy, often those who may feel little hope of ever living a seizure-free life. Its integrated medical care and clinical research present an unparalleled opportunity to progress knowledge and understanding about a much misunderstood condition.
Clare Pelham, Chief Executive of the Epilepsy Society, said: “Our goal is that epilepsy should be as insignificant in a person's life as perhaps having freckles - no impediment to living a full life, driving a car or holding down a demanding job. We really believe that genomics gives us the tools to make this a reality and we are delighted to be collaborating with UCB, bringing together our cutting-edge science and world class technology. Already in clinics we are making diagnoses that are changing people's lives, giving those whose days have been overshadowed by the possibility of a seizure, the chance of a seizure-free, and a care-free, life. And that is immense. We hope, in the future, this sort of diagnosis will become available to everyone across the UK.”
“Working together with the Epilepsy Society we now have an exciting opportunity to develop unique insights into this condition, which will provide a platform to inform our scientific and drug discovery approaches” explained Dr Dhaval Patel, Executive Vice President and Chief Scientific Officer at UCB. “We hope this collaboration could help in the development of tools to better identify difficult to treat patients earlier, and ultimately to develop tailored and targeted medicines which could bring significant value to these patients in the future.”
UCB will invest around €2.5 million over the course of the collaboration, which will be a key part of the pharmaceutical company’s wider commitment to maintain the UK’s position as a leading force in life sciences. This announcement follows UCB’s decision to invest £1 billion into the UK life-sciences sector over the next five years, which includes building its new R&D site in or around the Slough area.
This collaboration will also build on NHS England’s 10 Year Plan, which highlighted genomics as a key area for investment, outlining its aim to be the first national health care system to offer whole genome sequencing as part of routine care.1
Announcement of this collaboration coincides with International Epilepsy Day, a joint initiative created by the International Bureau for Epilepsy (IBE) and the International League Against Epilepsy (ILAE), which aims to raise awareness and understanding about epilepsy around the world. Further information about International Epilepsy Day is available online: https://internationalepilepsyday.org/about/
For further information:
Corporate Communications
Jim Baxter, Neurology Communications, UCB
T+32.2.473.78.85.01, jim.baxter@ucb.com
Ross Carroll, Head of External Engagement, UCB (BII)
T +44.1753-44 7610, ross.carroll@ucb.com
Investor Relations
Antje Witte, Investor Relations, UCB
T+32.2.559.94.14, antje.witte@ucb.com
Isabelle Ghellynck, Investor Relations, UCB
T +32.2.559.9588, isabelle.ghellynck@ucb.com
About the Epilepsy Society
Epilepsy Society was first established in 1892 and is the leading epilepsy medical charity in the UK2. Epilepsy Society’s vision is that by 2042 - the 150th birthday of the charity - no-one in the UK will find that a diagnosis of epilepsy adversely affects their quality of life and that epilepsy has become irrelevant or insignificant; perhaps in the same way as minor short-sightedness. Its mission is to enhance the quality of life of people affected by epilepsy by promoting public awareness and education, undertaking research and by delivering specialist care and support services. Doctors and scientists at the charity are making a major contribution to the world's research into the causes, diagnosis and treatment of epilepsy, pioneering novel diagnostic techniques and making possible improvements in both surgical and medical treatment of the condition.
About UCB
UCB is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases in immunology or neurology. With more than 7500 people in approximately 40 countries, the company generated revenue of € 4.5 billion in 2017. UCB is listed on Euronext Brussels (symbol: UCB).
Forward looking statements - UCB
This press release contains forward-looking statements based on current plans, estimates and beliefs of management. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including estimates of revenues, operating margins, capital expenditures, cash, other financial information, expected legal, political, regulatory or clinical results and other such estimates and results. By their nature, such forward-looking statements are not guarantees of future performance and are subject to risks, uncertainties and assumptions which could cause actual results to differ materially from those that may be implied by such forward-looking statements contained in this press release. Important factors that could result in such differences include: changes in general economic, business and competitive conditions, the inability to obtain necessary regulatory approvals or to obtain them on acceptable terms, costs associated with research and development, changes in the prospects for products in the pipeline or under development by UCB, effects of future judicial decisions or governmental investigations, product liability claims, challenges to patent protection for products or product candidates, changes in laws or regulations, exchange rate fluctuations, changes or uncertainties in tax laws or the administration of such laws and hiring and retention of its employees. UCB is providing this information as of the date of this press release and expressly disclaims any duty to update any information contained in this press release, either to confirm the actual results or to report a change in its expectations.
There is no guarantee that new product candidates in the pipeline will progress to product approval or that new indications for existing products will be developed and approved. Products or potential products which are the subject of partnerships, joint ventures or licensing collaborations may be subject to differences between the partners. Also, UCB or others could discover safety, side effects or manufacturing problems with its products after they are marketed. Moreover, sales may be impacted by international and domestic trends toward managed care and health care cost containment and the reimbursement policies imposed by third-party payers as well as legislation affecting biopharmaceutical pricing and reimbursement.
[1] NHS England. The NHS Long Term Plan, p76. https://www.longtermplan.nhs.uk/wp-content/uploads/2019/01/nhs-long-term-plan.pdf. Last accessed: January 2019
[2] Epilepsy Society. Epilepsy Society Facts. https://www.epilepsysociety.org.uk/epilepsy-society-facts#.XEXuuFz7Tcs. Last accessed: January 2019.
Record changed: 2023-06-05 |
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