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Austrian Drug Screening Institute. (11/30/12). "Press Release: High Content Screening with Tailored Clinically Relevant Assays". Innsbruck.

Region Region Innsbruck
  Country Austria
Organisations Organisation Austrian Drug Screening Institute GmbH (ADSI)
  Group University of Innsbruck
  Organisation 2 Medical University Innsbruck (MUI)
Product Product drug screening (service)
Persons Person Huber, Lukas (Medical Univ Innsbruck 201211 Professor + Director of the Biocenter)
  Person 2 Bonn, Günther (Univ Innsbruck 201211 Professor + Scientific Director at ADSI)

ADSI, the Austrian Drug Screening Institute, a new research institute of the Leopold Franzens University of Innsbruck (LFU) has opened its doors this week. It offers contract research for companies and academic research institutes. The special thing about ADSI is on the one hand that the cell-based assays are tailored in the way that they are particularly clinically relevant. On the other hand as much parameters as possible of these assays are read out with High Content Screening. This allows a quick and systematic scan of focused substance libraries for effective candidates (hits) in view of various medical questions.

Active substance candidates with better chances

ADSI does not limit its efforts to simply answering the question "is effective or is not". ADSI provides the explanation how and why a substance is effective and whether side effects are to be expected. This information allows to better assess the chances of active substances for clinical trials. Therefore ADSI not only offers the ideal platform for discovering active substance candidates but also provides a special environment to characterize more precisely first hits of a previous high throughput screening (hit to lead) and constantly develop them.

Co-cultures, analytics and toxicity tests

The particular strengths of ADSI are on all levels of the early active substance development:

1. Special extraction procedures and chemical analytics allow to optimize the production of effective substance mixtures in particular plant extracts.

2. The screening of co-cultures consisting of different cell types is conducted in controlled oxygen conditions. In doing so the cell systems are monitored over a longer period with state-of-the-art analytical methods in order to investigate the influence of test substances on cell communication and transmission of signals and clarify what happens with the test substances in cellular metabolism.

3. Toxicological tests give first information on the tolerability of test substances. This results in a profound, significant screening result which is decisive for the further development.

Management and Cooperations

ADSI was initiated by the cell biologist Prof. Lukas Huber, director of the Biocenter, Innsbruck Medical University, and Prof. Günther Bonn, director of the Institute of Analytical Chemistry and Radiochemistry, Leopold Franzens University of Innsbruck as well as the company Bionorica. Prof. Bonn and Prof. Huber are the Scientific Directors of ADSI.

The company Bionorica is the first partner company taking advantage of the Institute's screening service to develop effective plant extracts for phytomedicine so that ADSI is characterized by a special expertise in the screening of natural substances. Further partnerships with companies and public research institutions are planned within the scope of public private partnerships.

ADSI benefits from the proximity to Innsbruck's hospitals and the close cooperation with the Center for Personalized Cancer Medicine Oncotyrol, in which promising candidates can be further optimized with company partners for preclinical and clinical development.

Record changed: 2017-04-02


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