Advertisement

Picture EBD Group BIO-Europe 2019 Partnering Open BEU2019 650x80px
Document › Details

Symphogen A/S. (3/7/11). "Press Release: Symphogen Receives US Patent on Lead Cancer Compound Sym004. Sym004 Anti-cancer Activity Highlighted at Major Oncology Meeting". Paris.

Region Region United States (USA)
Organisations Organisation Symphogen A/S
  Group Symphogen (Group)
  Organisation 2 University of Barcelona
Products Product Sym004 (anti-cancer pAb)
  Product 2 antibody cancer drug
Person Person Drejer, Kirsten (Symphogen 2000–201608 Founding CEO since 201609 Executive Director)
     


Symphogen, a private biopharmaceutical company developing superior antibody therapeutics, said the company had been granted a US patent for Sym004 as well as other antibody compositions containing at least two distinct anti-EGFR antibodies having certain binding characteristics. The United States Patent and Trademark Office on February 15, 2011 issued to the company U.S. Patent No. 7,887,805, titled "Recombinant anti-epidermal growth factor receptor antibody compositions." The US patent provides protection through 2028. Patent applications are pending in additional countries.

Separately, Symphogen said that preclinical data demonstrating the superiority of the now proprietary Sym004 to the reference monoclonal antibody (mAb) was highlighted today in Paris, France in a Plenary Session of the 9th International Symposium on Targeted Anticancer Therapies (TAT Symposium). Sym004 is a novel drug candidate based on a 1:1 mixture of two anti-EGFR monoclonal antibodies (mAbs) directed against distinct non-overlapping epitopes in EGFR extracellular domain III.

… Preclinical data at TAT Symposium

Preclinical data presented today at the TAT Symposium in Paris, showed Sym004, a novel and proprietary candidate for the treatment of solid tumors, exhibited more pronounced growth inhibition in vitro and superior efficacy in in vivo models as compared to the reference anti-EGFR mAb cetuximab. The rate at which Sym004 induced rapid and efficient removal of the ligand-binding receptor from the cancer cell surface by triggering EGFR internalization and degradation was reported to have exceeded that of cetuximab. Like anti-EGFR mAbs in current clinical use, Sym004 has been previously shown to inhibit cancer cell growth and survival by blocking ligand-binding receptor activation and downstream signaling. Dr. Rodrigo Dienstmann, MD, Medical Oncologist, of the Vall d'Hebron University Hospital in Barcelona, Spain made the oral presentation entitled titled: "Sym004: A novel synergistic anti-EGFR antibody mixture with superior anti-cancer efficacy." The abstract will be published in the April 20 issue of Annals of Oncology.

… Sym004 to be highlighted at AACR and other meetings

The preclinical safety and pharmacokinetic data for Sym004 has been accepted for a poster presentation at the upcoming 102nd Annual meeting of the American Association for Cancer Research in Orlando, Florida April 2-6, 2011.
Later this year, Symphogen plans to present safety data from its first clinical study of Sym004 at a major medical meeting. Sym004 is currently being evaluated for the treatment of advanced solid tumors with particular focus in patients with KRAS wildtype advanced metastatic colorectal cancer (mCRC) that have previously progressed to standard chemotherapy and marketed anti-EGFR mAbs. A phase I-II, first-in-human study is presently ongoing at centers in USA and Spain. The main objective of the phase I component of the trial is to evaluate the safety and tolerability of multiple ascending doses of Sym004 in patients with solid tumors. The phase II part of the trial will include patients with mCRC and begin in the first quarter of 2011.

According to Kirsten Drejer, Ph.D., Chief Executive Officer of Symphogen, "The issuance of a US Patent is clearly a key milestone achievement for the company as the patent provides protection through 2028 and reinforces our leadership in innovative new antibody-based cancer therapy. The fact that major oncology meetings have chosen to highlight our data is equally important as we build awareness for our clinical opportunities. We are confident that a drug based on a mixture of antibodies as opposed to a single antibody has the potential to target EGFR more effectively than mAbs used today in clinical settings."

About Sym004

Sym004 is the company's lead clinical candidate in oncology. It inhibits cancer by blocking ligand binding, receptor activation/phosphorylation, downstream signaling, and has also shown a unique ability to induce rapid and efficient removal of the EGFR receptors from the cancer cell surface by inducing EGFR internalization and degradation in preclinical studies. In preclinical studies Sym004 was significantly more effective than the two marketed EGFR inhibitors, cetuximab and panitumumab, and has the potential to treat tumors with acquired resistance to other EGFR-targeted agents, including both monoclonal antibodies and small molecule tyrosine kinase inhibitors.


About Symphogen

Symphogen is developing superior antibody therapeutics (monoclonal and monoclonal mixtures) to help people with serious diseases and significant unmet medical needs. With its proprietary, unique Symplex™ discovery and Sympress™ manufacturing platforms, the company captures the diversity and specificity of the natural immune response in rationally designed recombinant antibody compositions. Symphogen is maturing a diversified pipeline of internal and partnered products across multiple indications including cancer, autoimmune and infectious disease. Symphogen is a private biopharmaceutical company, headquartered in Copenhagen, Denmark. For more information, please visit www.Symphogen.com.

Contacts:
Kirsten Drejer, Chief Executive Officer of Symphogen:
Phone no.: +45 45 26 50 59 or +45 22 10 99 59 (cell);
Email: kd@symphogen.com

Media:
Shari Annes
Cell: +1 6508880902
Email: sannes@annesassociates.com

   
Record changed: 2015-08-10

Advertisement

Picture [LSA] Life-Sciences-Asia.com – The Business Web Portal 650x89px

More documents for Symphogen (Group)


To subscribe to our free, monthly newsletter for the European life sciences, please send an e-mail to info@iito.de and simply fill the subject line with the word »LSE Newsletter«

To get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]

Advertisement

Picture EBD Group BIO-Europe 2019 Partnering Report BEU2019 650x80px




» top