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Sirion Biotech GmbH. (12/19/13). "Press Release: Sirion Biotech Licenses rights to Cevec Pharmaceuticals’ Immortalized Suspension Cells Derived from Primary Human Amniocytes for Its". Munich & Cologne.

Organisations Organisation Sirion Biotech GmbH
  Group Sirion Biotech (Group)
  Organisation 2 Cevec Pharmaceuticals GmbH
  Group Cevec (Group)
Products Product CAP® technology (Cevec)
  Product 2 adeno-associated viral vector (AAV vector)
Index term Index term Sirion Biotech–Cevec: cell lines, 201312– license €na to CAP cell lines for expression of AAV vectors
Persons Person Thirion, Christian (Sirion Biotech 201106 Managing Director + Founder)
  Person 2 Kintzel, Wolfgang (Ayoxxa 201802 Managing Director + Science to Market Venture Capital + CEVEC Pharmaceuticals + Direvo)

Viral vectors made in human expression system allow for safer and more efficient production of novel vaccines and gene therapy

SIRION Biotech announced today it is now providing viral vectors for preclinical use to be expressed in CEVEC's CAP(R)-Technology. CAP(R) cell lines are designed for stable and transient protein production and achieve highest protein yields with authentic human glycosylation patterns. Adenovirus and AAV vectors expressed in CAP(R) cell lines not only allow for higher yields, they also meet most stringent safety requirements when it comes to material to be used for clinical trials.

CEVEC's CAP(R) cells, based on normal human amniocytes, have proven highly efficient in the production of a broad range of otherwise difficult to express glycoproteins. These molecules are produced at high titers with authentic post-translational modifications in serum-free suspension culture. Their ability to generate human glycosylation patterns also makes CAP(R) cells a valuable tool for vaccine production.

Viral AdenoONE(TM)- and AAV vectors designed to specifically modify these promising cell lines are of increasing relevance for preclinical and later clinical research. Researchers in discovery are now able to start working in cell systems that are of value throughout the clinical and larger scale manufacturing processes.

About SIRION Biotech:

SIRION Biotech was founded in Munich in 2006 with the idea of enabling novel cell models closer to reality than ever before. This required the assembly of an all-encompassing, novel viral vector platform. Both, designing de novo viral vectors and the subsequent creation of custom cell models will pave the way for superior compound development in the life sciences. SIRION's technologies have been validated in over 300 single projects with more than 100 academic and industrial partners. As a result, cell models for drug discovery and development have become highly reliable, as have the use of new viral vectors in gene therapy and vaccine studies.

About CEVEC Pharmaceuticals:

CEVEC Pharmaceuticals GmbH, operational since 2004 and located in Cologne, Germany, is a biopharmaceutical company that specializes in developing and producing therapeutic proteins, vaccines and monoclonal antibodies with human glycosylation patterns. CEVEC's novel proprietary and patent-protected human CAP(R) and CAP-T(R) expression systems are ideal for manufacturing complex biopharmaceutical molecules and various vaccines. CEVEC is licensing out its human cell-based expression platform as well as its own biobetter candidates through partnerships with renowned pharmaceutical and biotech companies.

Contact Sirion:

Dr. Christian Thirion
Am Klopferspitz 19
D-82152 Martinsried
Tel.: +49-89-700 961 99-15

Contact CEVEC:

Wolfgang Kintzel, CEO
CEVEC Pharmaceuticals GmbH
Gottfried-Hagen Straße 62
D-51105 Köln, Germany
phone +49 (0) 221-46 02 0800

Record changed: 2019-01-13


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