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Silence Therapeutics plc. (7/18/19). "Press Release: Mallinckrodt to Make an Equity Investment in Silence Therapeutics as Part of a Collaboration". London & Staines-upon-Thames.

Organisations Organisation Silence Therapeutics plc (LON: SLN)
  Group Silence Therapeutics (Group)
  Organisation 2 Mallinckrodt plc (NYSE: MNK)
  Group Mallinckrodt (Group)
Products Product RNAi drug (RNAi therapeutic)
  Product 2 SLN500 (Silence Therapeutics, C33 complement targeting)
Index terms Index term Silence Therapeutics–Mallinckrodt: investment, 201907 investment £4m with 5m new ordinary shares at 79p/share as part of collab = 6.5% share
  Index term 2 Mallinckrodt–Silence Therapeutics: RNAi drugs, 201907– collab developm + commercialisation $20m upfront + milestones + royalties plus $5m investment
Person Person Romano, Steven (Mallinckrodt 201907 CSO + EVP + non-executive Board Director at Silence Therapeutics)

Mallinckrodt to Make an Equity Investment in Silence Therapeutics as Part of a Collaboration to Develop and Commercialize RNAi Therapeutics for Complement-mediated Diseases

- Mallinckrodt Chief Scientific Officer Steven Romano, M.D. joins Silence Board as nonexecutive Director -

Mallinckrodt plc (NYSE: MNK), a global biopharmaceutical company, and Silence Therapeutics plc (LON: SLN), a leader in the discovery, development and delivery of novel RNA1 interference (RNAi) therapeutics for the treatment of serious diseases, announce that, further to the collaboration announced earlier today, Mallinckrodt, acting through a subsidiary company, has agreed to make an equity investment of $5 million in Silence Therapeutics.

Mallinckrodt is subscribing for a total of 5,062,167 new ordinary shares at an issue price of 79p per share, representing a 10 percent premium to Silence’s 20-day, volume-weighted average price. Application will be made to the London Stock Exchange for the admission of the 5,062,167 new ordinary shares to be subscribed for trading on AIM2. It is expected that dealings will commence at 8:00 a.m. BST3 on 24 July 2019. Immediately following admission, Mallinckrodt’s shareholding will represent 6.5 percent of Silence Therapeutics’ enlarged, issued share capital which will be 77,285,652 ordinary shares.

As part of this equity investment Mallinckrodt will take a non-executive Director seat on the Silence Board of Directors, and it has been proposed that Steven Romano, M.D., Executive Vice President and Chief Scientific Officer at Mallinckrodt fulfill this position. A further announcement, including the disclosures required under Rule 17 and Schedule Two paragraph (g) of the AIM Rules for Companies, will be made at the time of Dr. Romano’s appointment to the Board.

The separate collaboration between Mallinckrodt and Silence Therapeutics announced earlier today will allow the companies to develop and commercialize RNAi drug targets designed to inhibit or silence the complement cascade, a group of proteins that are involved in the immune system and that play a role in the development of inflammation. These proteins are known to contribute to the pathogenesis of many diseases, including autoimmune diseases.


Silence Therapeutics is developing a new generation of medicines by harnessing the body’s natural mechanism of RNA interference, or RNAi, within its cells. Its proprietary technology can selectively inhibit any gene in the genome, specifically silencing the production of diseasecausing proteins. Using its enabling delivery systems, it has achieved an additional level of specificity by delivering its therapeutic RNA molecules exclusively to target cells. Silence’s proprietary RNA chemistries and delivery systems are designed to improve the stability of our molecules and enhance effective delivery to target cells, providing a powerful modular technology well suited to tackle life-threatening diseases. Silence Therapeutics remains focused and is determined to be responsive to creating shareholder value as well as the appropriate growth and development of its business. Silence Therapeutics continues to assess a number of options in addition to its organic plan which it believes would be additive to the Company's

future growth prospects and shareholder value, which may include equity fundraisings as well as other strategic licensing and collaboration opportunities. For more information, please visit


Mallinckrodt is a global business consisting of multiple wholly owned subsidiaries that develop, manufacture, market and distribute specialty pharmaceutical products and therapies. The company's Specialty Brands reportable segment's areas of focus include autoimmune and rare diseases in specialty areas like neurology, rheumatology, nephrology, pulmonology and ophthalmology; immunotherapy and neonatal respiratory critical care therapies; analgesics and gastrointestinal products. Its Specialty Generics reportable segment includes specialty generic drugs and active pharmaceutical ingredients. To learn more about Mallinckrodt, visit

Mallinckrodt uses its website as a channel of distribution of important company information, such as press releases, investor presentations and other financial information. It also uses its website to expedite public access to time-critical information regarding the company in advance of or in lieu of distributing a press release or a filing with the U.S. Securities and Exchange Commission (SEC) disclosing the same information. Therefore, investors should look to the Investor Relations page of the website for important and time-critical information. Visitors to the website can also register to receive automatic e-mail and other notifications alerting them when new information is made available on the Investor Relations page of the website.

Cautionary Statements Related to Forward-Looking Statements


This release includes forward-looking statements concerning Mallinckrodt’s collaboration with Silence, including expectations regarding future research and development plans, potential milestone payments and commercial arrangements and the potential impact on patients. The statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those in the forward-looking statements: uncertainties inherent in research and development, including clinical trial results; satisfaction of regulatory and other requirements; actions of regulatory bodies and other governmental authorities; changes in laws and regulations; issues with product quality, manufacturing or supply, or patient safety issues; and other risks identified and described in more detail in the "Risk Factors" section of Mallinckrodt's most recent Annual Report on Form 10-K and other filings with the SEC, all of which are available on its website. The forwardlooking statements made herein speak only as of the date hereof and Mallinckrodt does not assume any obligation to update or revise any forward-looking statement, whether as a result of new information, future events and developments or otherwise, except as required by law.


The information contained within this announcement is deemed by the Silence Therapeutics plc to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain.


Investor Relations
Daniel J. Speciale, CPA Vice President, Investor Relations and IRO

Daniel Yunger
Kekst CNC


Dr. David Horn Solomon, Chief Executive Officer
Mr. Iain Ross, Non-Executive Chairman
+44 (0) 20 3457 6900

Peel Hunt/LLP (Nominated Adviser and Broker)
James Steel/Oliver Jackson
+44 (0) 20 7418 8900

European IR
Consilium Strategic Communications
Mary-Jane Elliott/Chris Welsh/Angela Gary
+44 (0) 20 3709 5700

Westwicke Partners
Peter Vozzo

Mallinckrodt, the "M" brand mark and the Mallinckrodt Pharmaceuticals logo are trademarks of a Mallinckrodt company. Other brands are trademarks of a Mallinckrodt company or their respective owners. © 2019 Mallinckrodt. 7/19

1 Ribonucleic acid

2 Alternative Investment Market, a sub-market of the London Stock Exchange

3 British Summer Time

Record changed: 2019-07-23


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