Picture EBD Group World of Partnering Opportunities 650x100px
Document › Details

Icagen, Inc.. (3/28/17). "Press Release: Icagen Announces Collaboration with Bayer to Develop Novel XRpro Assays". Durham, NC.

Organisations Organisation Icagen Inc. [new, since 0/15]
  Organisation 2 Bayer AG
  Group Bayer (Group)
Products Product XRpro® research assay
  Product 2 drug discovery
Index term Index term Bayer–Icagen: drug discovery assays, 201703– collab developm of XRpro Assays for early discovery programs in area of transporter targets
Person Person Krafte, Doug (Icagen 201703 CSO)

Today the Target-to-Lead company Icagen announces a collaboration with Bayer to develop new X-ray fluorescence assays using the proprietary XRpro® platform. These assays are designed to help Bayer to progress various early discovery programs in the area of transporter targets.

A major obstacle for validation of transporters as targets and subsequent identification of molecules targeting transporters has been the lack of a broadly applicable high-throughput screening platform, especially for non-electrogenic transporters. To date, screening of non-electrogenic transporters in HTS mode can still be challenging and in certain cases is only achieved with indirect readouts. The XRpro® technology employs X-ray fluorescence as a method that enables a high throughput assessment of electrogenic and nonelectrogenic transporters, and is particularly well suited for certain classes of inorganic transporters.

"Icagen looks forward to collaborating with Bayer on this ground-breaking project," said Dr. Doug Krafte, Icagen's CSO. "XRpro represents a unique application of X-ray fluorescence technology and has the potential to unlock new drug discovery e?orts for previously untouched molecular targets."

The project has established key milestones and has the potential to span two years.

About XRpro

The XRpro® technology leverages the unique capabilities of X-ray fluorescence for high throughput analysis of plasma membrane ion channels and transporters, including non-electrogenic symporters and antiporters. XRpro® is a label-free technology that directly quantifies ion flux in cell populations without dyes, fluorophores, and radiolabels and o?ers the ability to conduct assays in complex bu?ers and media, including 100% serum. Biological elements with an atomic number of 16 (sulfur) or greater are measured simultaneously, including biologically important monovalent ions (e.g. K+), divalent ions (e.g. Ca2+), transition metals (e.g. Zn2+), halogens (e.g. Cl-), and tracer ions (e.g., Rb+, Sr2+).

About Icagen

Icagen partners with global pharmaceutical and biotech companies to generate high-quality, advanced leads. As a focused, Target-to- Lead (T2L) company, Icagen works with collaborators in multi-year, integrated drug discovery programs as well as piecemeal projects to fill-in the gaps for R&D e?orts. Born from a biotech background and matured by pharma companies, Icagen brings to partners a North American team with over 20 years of experience in early discovery. The process of drug discovery starts with druggable targets.

Icagen scientists have vast experience in target-based drug discovery, including ion channels, kinases, GPCR's and transporters. The Icagen team works with collaborators to determine target feasibility using state-of-the-art computational chemistry methods. Once a target is selected, the team combines virtual screening, ultra-high throughput screening (uHTS), biology and medicinal chemistry to generate viable leads in an iterative process. For more information email

Record changed: 2023-06-05


Picture Berlin Partner Top News Healthtech Company Mika 650x200px

To subscribe to our free, monthly newsletter for the European life sciences, please send an e-mail to and simply fill the subject line with the word »LSE Newsletter«

Find more infos about advertising at [iito] web portals in our media flyer [iito] in a Nutshell [PDF file]


Picture EBD Group World of Partnering Opportunities 650x300px

» top