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Genespire S.r.l.. (9/12/24). "Press Release: Genespire Appoints Karen Aiach-Pignet as Chief Executive Officer". Milan.

Organisations Organisation Genespire S.r.l.
  Organisation 2 Lysogene S.A. (Euronext Paris: LYS)
Product Product  lentiviral vector
Persons Person Aiach-Pignet, Karen (Genespire 202409– CEO before Lysogene CEO + Founder)
  Person 2 Berretta, Julia (Epsilen Bio 202006– CEO + Genespire 202004–202409 CEO before Cellectis 2014–201812 VP BusDev)
     


Karen’s appointment bolsters Genespire’s position as a leader in in-vivo lentiviral gene therapy


Genespire, a biotechnology company developing off-the-shelf gene therapies for pediatric patients affected by genetic diseases, today announces the appointment of Karen Aiach-Pignet as Chief Executive Officer following Dr. Julia Berretta, the former CEO, stepping down.

Karen has an outstanding track-record in gene therapy applied to genetic neurodegenerative diseases having founded and led Lysogene, a global leader in the field. During her tenure, she pioneered the development of an adeno-associated virus (AAV) vector for patients with the rare neurodegenerative condition Sanfilippo Type A, initiated and executed an international Phase 3 gene therapy clinical trial, and raised funds via partnering deals and by listing the company on the Euronext Stock Exchange.

Karen joins Genespire as the company progresses lead candidate, GENE202, for the treatment of methylmalonic acidemia (MMA) into clinical development. MMA is a devastating genetic disorder impairing the metabolism of certain amino acids and fats. Onset occurs in early infancy, is associated with significant mortality and morbidity, and there are currently no disease-modifying treatments available. Genespire’s technology has the potential to help treat many other genetic diseases with a one-time, off-the-shelf treatment, for both adult and pediatric patients.

Karen Aiach-Pignet, CEO at Genespire, commented: “I strongly believe in a better world for patients with metabolic diseases. Leading Genespire, with the aim to develop and deliver safe and efficacious life changing therapies for patients with substantial needs, is therefore a huge honour. Our unique ISLV technology platform, our investors, the team and I, will all come together to make this company a success. Embarking on this new partnership with Sofinnova Partners and working with other high-profile investors, provides huge endorsement for what we are aiming to achieve.”

Joern Aldag, Chairman at Genespire, commented: “I am incredibly proud of what the Genespire team has achieved and would like to thank Dr. Julia Berretta, our previous CEO, for her excellent work over the past four and a half years and for orchestrating a seamless transition of leadership. We wish her all the best for the future.

“Karen’s extensive experience and knowledge in the development of gene therapies for rare diseases and paediatric indications is a true inspiration. She has incredible drive, ambition and the ability to deliver fast results which will be an invaluable asset to Genespire as we progress our lead lentiviral-based therapy into the clinic.”

In addition to her many prestigious accomplishments, Karen is a founding executive member of the International Rare Diseases Research Consortium, was a Member of the Paediatric Committee at the European Medicines Agency and served on the French Ethical Review Board at Ambroise Paré Hospital. She has supported several not-for-profit organizations engaged in advocacy and research in the field of rare diseases. Acknowledgements of Karen’s work include the Ordre National du Merite, a French order of merit, awarded by the French President.

Karen recently studied Digital Health at Harvard Business School. She is a graduate from the ESSEC Business School and majored in Economics at the Institut d’Études Européennes of University Paris 8.


-ENDS-


Enquiries:

Genespire
Tel: +39 02 80896651
info@genespire.com

ICR Consilium
Tel: +44 (0) 20 3709 5700
Amber Fennell/Ashley Tapp/Jonathan Edwards
Genespire@consilium-comms.com


About Genespire

Genespire is a biotechnology company, developing off-the-shelf gene therapies based on immune shielded lentiviral vectors (ISLVs) for pediatric patients affected by genetic diseases. ISLVs are designed to be used intravenously and allow the life-long production of the therapy directly from the patient’s liver. Genespire is initially advancing therapeutic programs in inherited metabolic diseases with high unmet medical need. Based in Milan, Italy, Genespire was founded in March 2020 by gene therapy pioneers Prof. Luigi Naldini and Dr. Alessio Cantore, Fondazione Telethon and Ospedale San Raffaele. Genespire is a spin-out of SR-Tiget, a world leading cell and gene therapy research institute. Find out more about us at www.genespire.com.

   
Record changed: 2024-09-29

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