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Forge Therapeutics, Inc.. (12/22/15). "Press Release: Forge Therapeutics Receives Exclusive License for Intellectual Property on Metalloprotein Inhibitors from University of California, San Diego". San Diego, CA.

Region Region ALL
Organisations Organisation Forge Therapeutics Inc.
  Organisation 2 University of California, San Diego (UCSD)
  Group University of California (System)
Products Product LpxC inhibitor
  Product 2 drug discovery
Person Person Zimmerman, Zachary A. (Forge Therapeutics 201612 CEO)

Forge Therapeutics, Inc., a biotechnology company developing innovative medicines using a breakthrough drug discovery platform targeting metalloproteins, announced today it has obtained an exclusive license from the University of California San Diego to patent rights related to novel metalloprotein inhibitors discovered in the laboratory of Forge Therapeutics scientific co-founder Professor Seth Cohen, Ph.D.

"We are pleased to obtain exclusive worldwide rights to this intellectual property, which adds to our expanding and dominant patent portfolio protecting the development and commercialization of metalloprotein inhibitors," said Zachary A. Zimmerman, Ph.D., CEO of Forge Therapeutics. "In addition to strengthening our patent portfolio, we continue to apply our expertise in bioinorganic chemistry to discover and develop novel inhibitors against validated targets, potentially overcoming previous chemistry limitations in the industry."

The licensed technology relates to the discovery of novel metal-binding pharmacophores toward LpxC, a zinc metalloenzyme found only in Gram-negative bacteria, and uses of these pharmacophores to inhibit LpxC for therapeutic benefit in treating Gram-negative bacteria infections.

The Centers for Disease Control and Prevention estimates that drug resistant bacteria cause 23,000 deaths and 2 million illnesses each year in the United States. Among all of the bacteria resistance problems, Gram-negative bacteria are particularly worrisome because they are becoming resistant to nearly all drugs that would be considered for treatment. Gram-negative bacteria cause infections including pneumonia, bloodstream infections, wound or surgical site infections. The high priority Gram-negative organisms include Klebsiella, Acinetobacter, Pseudomonas aeruginosa, and E. coli.

LpxC is a zinc-dependent metalloenzyme required for the outer membrane of Gram-negative bacteria, and inhibition of LpxC has antimicrobial activity. LpxC is an attractive antibacterial target as there is no human homologue and it is highly conserved in Gram-negative bacteria. As inhibitors of LpxC are not among the approved antibiotics currently prescribed for the treatment of bacterial infections, compounds targeting LpxC would likely overcome pre-existing drug-resistance mechanisms. Various small molecule LpxC inhibitors have been reported, however, the majority of the highly potent compounds rely on hydroxamate chemistry to bind zinc in the enzyme catalytic site. Unfortunately, hydroxamates suffer from liabilities including high clearance, low bioavailability, and metabolism that leads to toxic byproducts. Forge Therapeutics has developed a non-hydroxamate LpxC inhibitor that is potent, on-target, well-tolerated, and efficacious in an animal infection model.

The Forge Therapeutics patent estate covers over 300 distinct metal binding pharmacophores and their uses for the inhibition of metalloprotein targets. In addition, Forge has patent protection related to select targets including LpxC. This layered approach protects the Forge platform technology as well as methods of inhibition for any metalloprotein.

About Forge Therapeutics, Inc.

Forge Therapeutics, Inc. ("Forge") is a biotechnology start-up that leverages its novel chemistry platform to develop small molecule inhibitors to target metalloproteins. Metalloproteins are proteins that require metal ions for their biological function and make up over 1/3 of the proteins in the human body. Forge uses a proprietary approach comprised of molecular modeling for rational drug design along with fundamental knowledge and expertise in bioinorganic chemistry to target metalloproteins. The name Forge Therapeutics comes from two definitions for forge: to manipulate (inhibit) a metal object (metalloprotein) and to move forward steadily with a purpose (the Forge team). Forge Therapeutics, Inc., maintains its headquarters in San Diego, California. To learn more please visit


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