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F2G Ltd.. (1/7/19). "Press Release: F2G Expands Investor Syndicate and Progresses Phase IIb Study for Novel Antifungal". Manchester.

Organisations Organisation F2G Ltd.
  Group F2G (Group)
  Organisation 2 Morningside Venture Investments (Morningside Ventures)
  Group Morningside (Chan family of Hong Kong) (Group)
Products Product olorofim (F901318)
  Product 2 venture capital
Persons Person Nicholson, Ian (F2G Ltd 201303– CEO + Partner at Advent Life Sciences before Chroma Therapeutics CEO + Celltech + OGS)
  Person 2 Dinges, Jason (Morningside 201602 Investment Manager)

> New investor Morningside Venture joins existing blue-chip investor syndicate

> Company accelerates global phase 2b study of lead candidate olorofim to develop its novel antifungal in an area of high unmet medical need

F2G Ltd, a UK- and Austria-based Biotech developing novel therapies for life-threatening fungal infections, today announced that it has raised funding from life science investor Morningside Venture Investments Ltd. (Morningside). This funding follows a EUR 24 million loan from the European Investment Bank (EIB) in November 2018 and allows F2G to accelerate its worldwide Phase 2b study for its lead candidate olorofim (formerly F901318) as a treatment for invasive fungal infections due to difficult to treat moulds such as azole-resistant aspergillosis.

F2G has discovered and is developing the orotomides, a novel class of antifungal agents. The orotomides act via a different mechanism than currently marketed antifungal agents and are active against Aspergillus and other rare and resistant moulds. Due to their mechanism of action, orotomides have fungicidal activity against fungal infections resistant to current therapies, a growing global problem where limited treatment options have led to a high medical need.

The Phase 2b study for olorofim is a global open-label study in patients who have limited treatment options for difficult-to-treat invasive fungal mould infections such as azole-resistant aspergillosis, scedosporiosis, lomentosporiosis, and other rare mould infections. There will be study sites across at least 6 countries. With 12 centres open in 5 countries (AU, BE, ES, NL, US), investigators in the study are recruiting patients well ahead of schedule. A further 20 centres will open in 2019. Olorofim is being developed both as IV and oral formulations.

Ian Nicholson, CEO of F2G Ltd commented: “The investment from Morningside represents further validation and support of our strategy to develop a new, first-in-class anti-fungal drug. Morningside’s addition further strengthens our investor syndicate which includes Novo Holdings, Advent Life Sciences, Merifin Capital and Brace Pharma, who represent a renowned and committed shareholder base with a track record of supporting successful next-generation companies.

“The recent funding from the EIB along with this additional investment from Morningside will allow F2G to progress the development of our lead candidate olorofim for a patient population with very limited treatment options and a high medical need. Recruitment for our phase 2b programme is ongoing and has already seen the enrolment of patients in Europe, Australia, and the US.”

Jason Dinges, an investment advisor to Morningside added: “We believe F2G’s programmes have the potential to bring real impact in the treatment of life-threatening fungal diseases. We are very excited to support this proven management team as it seeks to further the development of olorofim in treating drug-resistant Aspergillus species and other rare moulds.”

In November 2018, F2G’s Austrian branch, F2G Biotech GmbH, received a EUR 24 million loan from the European Investment Bank (EIB) under the ‘InnovFin – Infectious Diseases Finance Facility’ (IDFF) run under Horizon 2020, the EU research and innovation programme. The EIB financing recognises the potential of orotomides, a completely new class of antifungal agents to treat life-threatening fungal diseases.


F2G Ltd
Ian Nicholson | Chief Executive Officer
Ralf Schmid | Chief Financial Officer
Tel: +44 (0)161 785 1271 (UK)
+43 (0)1 997 4267 (A)

Optimum Strategic Communications
Mary Clark / Supriya Mathur / Ellie Blackwell
Tel: +44 (0) 203 950 9144

About F2G

F2G is a world-leading UK- and Austria-based Biotech company (F2G Ltd and F2G Biotech GmbH) focused on the discovery and development of novel therapies to treat life-threatening invasive fungal infections. F2G has discovered and developed a completely new class of antifungal agents called the orotomides. The orotomides target dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway. This is a completely different mechanism from that of the currently marketed antifungal agents and gives the orotomides fungicidal activity against a broad range of rare and resistant fungal mould infections. Olorofim (formerly, F901318) is F2G’s leading candidate from this class and is in a Phase 2b open-label study focussing on rare and resistant invasive fungal infections such as aspergillosis (including azole-resistant strains), scedosporiosis, and lomentosporiosis. Olorofim is being developed both as IV and oral formulations.

Morningside Group

Morningside is a diversified investment group founded in 1986 by the Chan family of Hong Kong. It is engaged primarily in private equity and venture capital investments. The group has investments in North America, Europe, across Asia-Pacific, and since 1992, in Mainland China. Morningside is an active investor in early-stage life science companies formed around new technologies that represent a high degree of novelty over existing technologies. More information is available at

Record changed: 2023-06-05


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