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Evotec AG. (5/2/12). "Press Release: Evotec Grants Exclusive Rights on EVT 401 in China to Conba Pharmaceutical. License Granted to One of the Largest Pharmaceutical Companies in China". Hamburg.

Region Region China
Organisations Organisation Evotec AG (FSE: EVT, TecDAX)
  Today Evotec SE (FSE: EVT, MDA X/TecDAX)
  Group Evotec (Group)
  Organisation 2 Zhejiang Jinhua Conba Pharmaceuitcal Co., Ltd.
  Group Conba (Group)
Products Product EVT 401
  Product 2 P2X7 antagonist
Person Person Lanthaler, Werner (Evotec AG 200903– CEO before Intercell AG CFO before Austrian Industrial Assoc before McKinsey)



Evotec AG (Frankfurt Stock Exchange: EVT, TecDAX) and Conba Pharmaceutical Co., Ltd. announced today the grant of a development and marketing license on EVT 401, a selective, small molecule P2X7 antagonist, for human indications with exception of ophthalmological, chronic obstructive pulmonary disease (COPD) and endometriosis in China.

Evotec receives a small upfront payment, development and commercial milestone payments in excess of € 60 m, and tiered double-digit royalties on net sales. The agreement grants Conba Pharmaceutical exclusive rights to develop and commercialise the compound for the Chinese market. Evotec will have the right to reference clinical data produced by Conba Pharmaceutical to support potential further development of EVT 401 in other territories.

P2X7 receptor antagonism may provide a novel approach for the treatment of inflammatory conditions. Evotec has completed the first Phase I, single dose study of EVT 401 in 2010. Conba Pharmaceutical will initiate further clinical trials with EVT 401 in China in inflammatory diseases.

Dr Werner Lanthaler, CEO of Evotec said: "We are very pleased to partner with Conba, a leading Chinese pharmaceutical company, to tap into the Chinese market for inflammatory diseases, such as rheumatoid arthritis. This partnership will also increase the value of the P2X7 programme worldwide, and follows our strategy to align with the best and most dedicated partners in the industry.

Yu Bin, General Manager of Conba Pharmaceutical comments: "We are delighted about the collaboration with Evotec, a global leader in drug discovery and development. This collaboration expands our ongoing strategy to become an innovator in China for pharmaceutical R&D. We are confident about the potential of this compound to become a novel treatment for inflammatory diseases."


The P2X7 receptor is an ATP-gated ion channel primarily expressed on cells of the immune system and is thought to play an important role in inflammatory processes through the regulation of a number of proinflammatory cytokines such as IL-1ß. Evotec has identified novel, orally bioavailable, potent and selective P2X7 antagonists from multiple proprietary chemical series. A candidate has been selected and has completed the first Phase I, single dose study. The study was a double-blind, placebo controlled study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of EVT 401. A total of 96 healthy male volunteers received single oral ascending doses of the compound as a suspension or capsule.

The compound was very safe and well tolerated and there were no serious adverse events or withdrawals. In addition, the pharmacodynamic assay used in this study demonstrated the ability of EVT 401 to block ATP-stimulated IL-1ß release in whole blood samples taken from subjects, thereby proving "on target" activity at well tolerated oral doses. In August 2011 EVT401 was partnered in animal health indication with a major animal health company.


Evotec is a drug discovery alliance and development partnership company focused on rapidly progressing innovative product approaches with leading pharmaceutical and biotechnology companies. We operate worldwide providing the highest quality stand-alone and integrated drug discovery solutions, covering all activities from target-to-clinic. The Company has established a unique position by assembling top-class scientific experts and integrating state-of-the-art technologies as well as substantial experience and expertise in key therapeutic areas including neuroscience, pain, metabolic diseases as well as oncology and inflammation. Evotec has long-term discovery alliances with partners including Boehringer Ingelheim, CHDI, Genentech, Medimmune/Astra Zeneca, and Ono Pharmaceutical. In addition, the Company has existing development partnerships and product candidates both in clinical and preclinical development. These include partnerships with Boehringer Ingelheim, MedImmune and Andromeda (Teva) in the field of diabetes, and with Roche in the field of Alzheimer's disease. For additional information please go to


Zhejiang Jinhua CONBA Pharmaceutical Co., Ltd. (Jinhua CONBA) is a major subsidiary of CONBA group, which is headquartered in Hangzhou. CONBA group is one of the major pharmaceutical companies in China and has more than twenty subsidiary companies. Founded in 1958, Jinhua CONBA is located in centrally located Jinhua Pharmaceutical Industry zone. It possesses total assets of RMB 500 million and achieved a turnover in 2011 of RMB 560 million. It has more than 1000 employees, over 40% of which have PhD levels. JINHUA CONBA produces both finished products and APIs including lyophilized powder for injection, capsules, tablets and antibiotics, semi-synthetic antibiotics and chemical synthetic bulk drugs. JINHUA CONBA is continually improving its quality management system and its facilities are certified according to European cGMP, U.S.A FDA , ISO9001, ISO14001 and Chinese GMP. It has a sales network which covers 50 major cities in China and Conba's products are widely exported to Europe, South America and Asia.

FORWARD LOOKING STATEMENTS - Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgement of Evotec as of the date of this report. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.

Record changed: 2019-06-09


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