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Evotec AG. (6/27/11). "Press Release: Milestone in an Ion Channel Drug Discovery Collaboration with Ono Pharmaceutical Co., Ltd. Achieved. Evotec Receives Milestone Payment frm Ono for the Progression of Novel Ion Channel Modulators into Lead Optimizatio

Organisations Organisation Evotec AG (FSE: EVT, TecDAX)
  Today Evotec SE (FSE: EVT, MDA X/TecDAX)
  Group Evotec (Group)
  Organisation 2 Ono Pharmaceutical Co., Ltd. (TSE: 4528)
  Group Ono Pharmaceutical (Group)
Products Product drug discovery services
  Product 2 lead optimisation (service)
Person Person Polywka, Mario (Evotec 2019– Supervisory Board Member before 201201–201812 COO RETIRED 12/18)

Evotec AG (Frankfurt Stock Exchange: EVT, TecDAX) today announced the achievement of specific success criteria in an ion channel research collaboration with Ono Pharmaceutical Co., Ltd. (Ono) and the receipt of a milestone payment. This collaboration project was initiated in October 2009 to identify small molecules targeting an ion channel implicated in cardiovascular, CNS and urological diseases in one and a half years and now successfully identified multiple compounds meeting various criteria in activity, selectivity and pharmacokinetic characteristics. Evotec and Ono now agree to continue this research collaboration until April 2012 and enter into lead optimisation with the goal to generate new chemical entities, which will have the potential to become new drug candidates. Ono has a worldwide right to develop and commercialize compounds generated by Evotec in this collaboration.

Dr Mario Polywka, Chief Operating Officer of Evotec, commented: "We are delighted to deliver high value molecules to our partner Ono and to expand our collaboration. We enjoy a very successful and close relationship. This achievement clearly demonstrates the value we bring to our alliance partners in the area of drug discovery. We look forward to continuing working closely with our colleagues at Ono."

"We are very pleased to achieve the research milestone and progress into lead optimisation with a project. We highly appreciate a wide range of drug discovery technologies at Evotec and the experiences of their scientists. We are confident that multiple preclinical candidates will be identified in near future" said Kazuhito Kawabata, Ph.D., Managing Director, Research Headquarters at Ono.

Contact: Dr Werner Lanthaler, Chief Executive Officer, Evotec AG, Phone: +49.(0)40.56081-242,

Forward-Looking Statements - Information set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgement of Evotec as of the date of this report. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.

Record changed: 2019-06-09


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