Domain Therapeutics S.A.. (1/23/17). "Press Release: Domain Therapeutics and Merck Enter into a License and Collaboration Agreement for Development of Adenosine Receptor Antagonists in Immuno-oncology". Strasbourg.

	Organisation	Domain Therapeutics S.A.
	Group	Domain Therapeutics (Group)
	Organisation 2	Merck KGaA
	Group	Merck (DE) (Group)
	Product	adenosine receptor antagonist
	Product 2	cancer immunotherapy (immuno-oncology, I-O)
	Index term	Merck (DE)–Domain Therapeutics: cancer drugs, 201701– collab developm + ww license to adenosine receptor antagonists
	Person	Neuville, Pascal (Domain Therapeutics 200812c– CEO)
	Person 2	Radvanyi, Laszlo (Merck (DE) 201511– Head of Global Immuno-oncology Research before CSO at Lion Biotechnologies)

Merck to develop Domain Therapeutics’ next generation adenosine receptor programs for use in combination with immune checkpoint inhibitors

Domain Therapeutics today announces that a collaboration and licensing agreement with Merck, a leading science and technology company, has been signed for the development of adenosine receptor antagonist drugs specifically designed for oncology and immuno-oncology.

The agreement will involve close collaboration between Merck and Domain Therapeutics to develop and test new agents targeting key adenosine receptors. Merck will support research activities and gain worldwide rights to Domain Therapeutics’ next generation of adenosine receptor inhibitors. Under the terms of the agreement, Domain will be eligible for more than EUR 240 million in milestones, as well as undisclosed royalties.

“With its growing portfolio of immuno-oncology agents, Merck is the ideal partner to develop our adenosine programs,” said Pascal Neuville, CEO, Domain Therapeutics. “As a strong collaborator with a leading investigational checkpoint inhibitor, we are confident that through Merck, our programs will progress rapidly.”

Adenosine has been identified as a key component in resistance mechanisms for many tumors targeted by immune check-point inhibitors. While blocking certain adenosine receptors has been shown to increase the response to immune checkpoint inhibitors, antagonizing other adenosine receptors has also been shown to slow tumor progression.

"This new generation of adenosine receptor antagonists is an important addition to our immuno-oncology pipeline,” said Laszlo Radvanyi, Senior Vice President, Head of Research in Immuno-Oncology at the biopharma business of Merck. “We plan to explore the promise of adenosine receptor antagonists and develop novel compounds to potentially use in new combination immunotherapies for cancer.”

About Domain Therapeutics S.A.

Domain Therapeutics is a biopharmaceutical company based in Strasbourg, France, dedicated to the discovery and early development of small molecules targeting G proteincoupled receptors (GPCRs), one of the most important classes of drug targets.

Domain Therapeutics identifies and develops new drug candidates, allosteric modulators and biased ligands through its innovative approach and distinctive technologies. The company provides access to its technologies through research and collaborative agreements and develops its own pipeline up to the stage of clinical candidate for major indications in central nervous system and oncology.

www.domaintherapeutics.com

Media contacts and analysts

Andrew Lloyd & Associates
Juliette dos Santos | Sandra Régnavaque
juliette@ala.com | sandra@ala.com
Tel: +33 1 56 54 07 00
@ALA_Group

Record changed: 2023-06-05