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Cellular Origins Ltd.. (5/29/24). "Press Release: Cellular Origins and Cell and Gene Therapy Catapult Collaborate to Demonstrate Universal Automation of CGT Manufacturing". Cambridge & Stevenage.

Organisations Organisation Cellular Origins Ltd.
  Group TTP Group (Group)
  Organisation 2 Cell and Gene Therapy Catapult (CGT Catapult) (GB)
  Group United Kingdom (GB) (govt)
Products Product cell and gene therapy manufacturing (CGT manufacturing)
  Product 2 Constellation™ robotic platform (Cellular Origins, TTP)
Persons Person Stone, Edwin (TTP Group 202405 CEO of Cellular Origins)
  Person 2 Durdy, Matthew (United Kingdom (govt) 2020– CEO of Cell and Gene Therapy Catapult before CBO joined 2012)

Partnership to develop and implement Cellular Origins’ robotic platform Constellation for universal automation of CGT manufacturing at CGT Catapult’s Stevenage Manufacturing Innovation Centre.

Cellular Origins, a TTP Company focused on enabling scalable, cost-effective, and efficient manufacture of cell and gene therapies (CGTs), and the Cell and Gene Therapy Catapult (CGT Catapult), an independent innovation and technology organisation specialising in the advancement of the cell and gene therapy industry, today announced a collaboration to demonstrate universal automation of CGT manufacturing.

The partnership will undertake the physical and digital integration of existing bioprocessing equipment at the CGT Catapult’s Stevenage Manufacturing Innovation Centre (MIC) using Cellular Origins’ robotic platform, Constellation™. By bringing together CGT Catapult’s expertise in GMP operations and optimisation with Cellular Origins’ Constellation, the goal will be to evidence the benefits of automation in real world applications and advance the fields’ understanding of how automation can impact the barriers to scale that have held progress back.

2023 was a landmark year for the CGT industry, further demonstrating the growing need to scale CGT manufacturing. With a total of seven therapies receiving FDA approval—a number predicted to rise even further in 20241. In addition, increasing recommendations from regulators for CGTs to be used as earlier line treatments2 will likely see the sector transition from treating thousands to up to 10’s or 100’s of thousands of patients in the coming years. Despite the anticipated surge in demand, a lack of capabilities to efficiently manufacture these therapies at scale has led to a widening divide between the number of doses produced and the number of patients that could benefit from them.

The unique benefit of Constellation is universal automation that fluidically and digitally integrates a wide range of existing bioprocessing equipment, with minimal change to both the biological process and the bioprocessing equipment. Constellation’s use of automated tube welding allows it to adapt to the process, consumables, and equipment, rather than the other way round and without the need to add new components or connectors. This enables therapy developers to scale their CGT therapy and treat greater patient numbers without the delays and risk of having to re-develop their manufacturing process.

Constellation will be based at the CGT Catapult’s Stevenage MIC in its digital and automation testbeds, a newly developed pre-Good Manufacturing Practice (GMP) space for collaborators to develop digital and automated solutions to challenges that arise in the manufacturing of advanced therapies. The Stevenage MIC is a GMP-compliant facility licensed for clinical and commercial ATMP production, focused on developing manufacturing processes at scale, speed, and according to GMP.

Dr Edwin Stone, CEO at Cellular Origins, commented: “The CGT Catapult is a world-leading specialist in the field of cell and gene therapy, and we are delighted to announce this collaboration, enabling us to access their expertise and leverage the full potential of Constellation to revolutionise CGT manufacturing at scale. CGT Catapult’s experience in establishing GMP facilities and optimising cell therapy manufacture is directly aligned with Cellular Origins’ mission to prove the impact automated manufacturing can have in transforming cell therapy production. Through this partnership, we will work to demonstrate an automated manufacturing approach that will provide a route for patients worldwide to access these life-saving therapies.”

Matthew Durdy, Chief Executive at the CGT Catapult, added: “Embracing automation is a key step that the cell and gene therapy industry must take to reduce costs, increase efficiency and meet the growing demand for advanced therapies.” He added: “Through working with leading robotics and software experts such as Cellular Origins, we aim to develop new strategies that increase levels of automation. This will help our collaborators access the benefits of these technologies, help make advanced therapies more affordable to healthcare systems, and help more patients receive life changing therapies.”

To find out more about Constellation, please visit:




About Cellular Origins

Cellular Origins, a TTP Company, is focused on enabling scalable, reproduceable and efficient manufacture of cell and gene therapies (CGTs).

Despite the incredible potential for CGTs in the treatment of disease, emerging therapies remain unavailable to many patients due to insufficient expertise and manufacturing capability for affordable production. With an increasing number of approved CGTs currently reaching the market, the disconnect between innovative therapies and manufacturing capabilities has led to an urgent need for solutions that provide large-scale access to cost-effective, next-generation therapeutics.

Created to provide therapeutic developers and CDMOs access to the equipment they want, at the scale they need, Cellular Origins is bringing advanced automation from the industry 4.0 revolution to the forefront of CGT.

Cellular Origins’ Constellation is a closed, configurable, robotic platform that enables scalable, reproduceable, cost-effective and space efficient advanced therapy manufacture, consisting of highly flexible mobile robots with proprietary future-proofed, automated effectors for sterile fluid transfer. The modular platform can be seamlessly integrated into new and existing workflows with minimal changes, alleviating the need for process redevelopment without constraining innovation.

To find out more about Cellular Origins and its innovative cell therapy manufacture solutions, please visit Follow Cellular Origins on Twitter (@CellularOrigins) and LinkedIn (@CellularOrigins).

About the Cell and Gene Therapy Catapult

The Cell and Gene Therapy Catapult is an independent innovation and technology organisation committed to the advancement of the cell and gene therapy industry with a vision of a thriving industry delivering life changing advanced therapies to the world. Its aim is to create powerful collaborations which overcome challenges to the advancement of the sector. The Cell and Gene Therapy Catapult works with Innovate UK. For more information, please visit or


Cellular Origins
Dr Edwin Stone, CEO

The Cell and Gene Therapy Catapult
Alice Deeley, Communications and Content Manager
Email: or

Record changed: 2024-06-05


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