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Alentis Therapeutics–SEVERAL: investment, 202411 financing round Series D $181.4m led by OrbiMed with co-leads Novo Holdings + Jeito Capital
Alentis Therapeutics AG. (11/12/24). "Press Release: Alentis Therapeutics Raises $181.4 Million in an Oversubscribed Series D Financing to Advance the Clinical Development of Anti-Claudin-1 ADCs in Solid Tumors". Basel.
> Financing led by OrbiMed with co-leads Novo Holdings and Jeito Capital
> Strengthened by substantial contributions from Frazier Life Sciences, Longitude Capital, RA Capital, and Catalio Capital, among others
> Proceeds will support development of first-in-class CLDN1 targeted medicines including Phase 1/2 studies of ALE.P02 and ALE.P03
Alentis Therapeutics (“Alentis”), the clinical-stage biotechnology company developing treatments for Claudin-1 positive (CLDN1+) tumors and organ fibrosis, announced today that it has raised $181.4 million in Series D financing, supported by a syndicate of top-tier biotech investors. The financing will support Alentis to develop a deep pipeline of CLDN1 targeted medicines for solid tumors.
The funding round was led by OrbiMed with co-leads Novo Holdings and Jeito Capital. New investors Frazier Life Sciences, Longitude Capital, Catalio Capital, Piper Heartland Healthcare Capital and Avego Bioscience Capital participated in the round. Significant backing was also received from existing investor RA Capital Management, along with support from Morningside Venture Investments, BB Pureos, Bpifrance through its InnoBio 2 fund, as well as other early institutional investors, all of whom have been instrumental to Alentis’ development path.
“This financing is a testament to the transformational potential of CLDN1 antibody-drug conjugates (ADCs) for the treatment of solid tumors,” said Roberto Iacone, Chief Executive Officer of Alentis. “Let me take this opportunity to extend a warm welcome to our new investors.” Dr. Iacone added, “We’re excited to execute our development strategy and deliver clinical data for our programs over the next 12-18 months.”
The proceeds of the financing will be used to conduct Phase 1/2 clinical trials of two first-in-class ADCs targeting CLDN1, ALE.P02 and ALE.P03, further development of the pipeline, and general corporate purposes.
The FDA recently cleared an IND application for a Phase 1/2 clinical trial of ALE.P02 (with a tubulin inhibitor) in advanced or metastatic CLDN1+ squamous solid tumors. The clinical trial is expected to commence Q1 2025. For ALE.P03 (with a topoisomerase I inhibitor), a first-in-human trial in patients with CLDN1+ tumors is planned to start in 2025.
Luca Santarelli, Chairman of Alentis said, “I am excited about the future of Alentis, especially after this very significant financing, and would like to welcome the new Board Members that will join after the closing of the transaction.”
OrbiMed Partner, Dina Chaya said, “With this financing, Alentis is now well positioned to advance its CLDN1 antibody-drug conjugates, which have the potential to be first and best-in-class therapies for the treatment of cancer.”
“ADCs have shown their potential to be highly effective cancer treatments,” said Naveed Siddiqi, Senior Partner at Novo Holdings, Venture Investments. “Alentis has an exciting pipeline of first-in-class ADCs and we are proud to have co-led this round. We are looking forward to seeing the data generated from the first clinical trials of ALE.P02 and ALE.P03.”
Dr. Rafaèle Tordjman, Founder and CEO of Jeito Capital said, “We are excited to co-lead this major new financing round for Alentis that further validates the strength of its pipeline. We look forward to continuing to bring our expertise to support their development.”
New Board of Directors Appointments
As part of the financing, three new Board Members will join the Alentis Board of Directors, further strengthening the business, science and drug development expertise at the Board level.
> Dina Chaya, Partner at OrbiMed, has over 20 years of experience in healthcare investments, specializing in biopharma and medical technology.
> Anna Chen, Principal at Frazier Life Sciences, where she has been involved with investing in and building many of Frazier Life Sciences’ biopharmaceutical portfolio companies over the past 7 years.
> Brian Liu, Managing Director at Longitude Capital, brings more than 10 years of biopharma consulting and investing experience, focusing on transformative healthcare innovation.
About ALE.P02 and ALE.P03
ALE.P02 and ALE.P03 are first-in-class ADCs designed by linking a potent cancer drug (a tubulin and topoisomerase I inhibitor, respectively) to our antibody that specifically targets a unique CLDN1 epitope exposed on cancer cells. This combination creates a powerful new tool to fight cancer with less toxicity than traditional cancer drugs. The IND application for ALE.P02 to commence a Phase 1/2 clinical trial in advanced or metastatic CLDN1+ squamous solid tumors was recently cleared by the FDA.
About Alentis Therapeutics
Alentis Therapeutics, the CLDN1 company, is a clinical-stage biotech developing breakthrough treatments for CLDN1+ tumors. CLDN1 is a previously unexploited target that plays a key role in the pathology of cancer and fibrotic disease. Alentis is the leading company pioneering anti-CLDN1 ADCs and antibodies to modify and reverse the course of select diseases.
Alentis was founded based on ground-breaking research in the laboratory of Prof. Thomas Baumert, MD at the University of Strasbourg and the French National Institute of Health and Medical Research (Inserm). Alentis is headquartered at the pharma-biotech hub in Basel, Switzerland with an R&D subsidiary in Strasbourg, France and clinical operations in the US. Visit www.alentis.ch
About OrbiMed
OrbiMed is a healthcare investment firm, with approximately $17 billion in assets under management. OrbiMed invests globally across the healthcare industry, from start-ups to large multinational corporations, through a range of private equity funds, public equity funds, and royalty/credit funds. OrbiMed seeks to be a capital provider of choice, providing tailored financing solutions and extensive global team resources to help build world-class healthcare companies. OrbiMed’s team of over 130 professionals is based in New York City, San Francisco, London, Shanghai, Hong Kong, Mumbai, Herzliya, and other key global markets. More info: www.orbimed.com
About Novo Holdings A/S
Novo Holdings is a holding and investment company that is responsible for managing the assets and the wealth of the Novo Nordisk Foundation. The purpose of Novo Holdings is to improve people’s health and the sustainability of society and the planet by generating attractive long-term returns on the assets of the Novo Nordisk Foundation. Wholly owned by the Novo Nordisk Foundation, Novo Holdings is the controlling shareholder of Novo Nordisk A/S and Novonesis A/S (Novozymes A/S) and manages an investment portfolio with a long-term return perspective. In addition to managing a broad portfolio of equities, bonds, real estate, infrastructure and private equity assets, Novo Holdings is a world-leading life sciences investor. Through its Seed, Venture, Growth, Asia, Planetary Health and Principal Investments teams, Novo Holdings invests in life science companies at all stages of development. As of year-end 2023, Novo Holdings had total assets of EUR 149 billion. www.novoholdings.dk
About Jeito Capital
Jeito Capital is a global leading Private Equity fund with a patient benefit driven approach that finances and accelerates the development and growth of ground-breaking medical innovation. Jeito empowers and supports managers through its expert, integrated, multi-talented team and through the investment of significant capital to ensure the growth of companies, building market leaders in their respective therapeutic areas with accelerated patients’ access globally, especially in Europe and the United States. Jeito Capital has €534 million under management and a rapidly growing portfolio of investments. Jeito Capital is based in Paris with a presence in Europe and the United States.
For more information, please visit www.jeito.life or follow us on Twitter or LinkedIn.
For more information please contact:
Investor contact:
Alentis Therapeutics
Rizwan Velji, Chief Business Officer
[email protected]
Alentis Therapeutics
Sariette Witte, Head of Communications
[email protected]
+41 78 245 7310
Media contact:
O Public Relations GmbH
O’Patrick Wilson
[email protected]
+41 78 888 4332
Record changed: 2024-11-12 |
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More documents for Alentis Therapeutics AG
- [1] Alentis Therapeutics AG. (11/12/24). "Press Release: Alentis Therapeutics Raises $181.4 Million in an Oversubscribed Series D Financing to Advance the Clinical Development of Anti-Claudin-1 ADCs in Solid Tumors". Basel....
- [2] Alentis Therapeutics AG. (9/3/24). "Press Release: Alentis Appoints Jonathan Freve CFO". Basel....
- [3] Alentis Therapeutics AG. (4/13/23). "Press Release: Alentis Therapeutics Closes $105 Million Series C Funding to Advance Transformational Medicines for Claudin-1". Basel....
- [4] Alentis Therapeutics AG. (2/17/23). "Press Release: Alentis Therapeutics Makes Key Leadership Appointments". Basel....
- [5] Alentis Therapeutics AG. (1/9/23). "Press Release: Positive Results from Single Ascending Dose Phase 1 Study of ALE.F02 Targeting Claudin-1". Basel....
- [6] Alentis Therapeutics AG. (11/9/21). "Press Release: Alentis Therapeutics Announces Board Appointments". Basel....
- [7] Alentis Therapeutics AG. (6/15/21). "Press Release: Alentis Therapeutics Raises USD 67 Million in Series B Financing". Basel & Strasbourg....
- [8] Jeito Capital. (6/15/21). "Press Release: Jeito Capital Becomes Key Investor in Alentis Therapeutics as Part of $67 Million Series B Financing Round". Paris....
- [9] BB Pureos Bioventures. (9/23/20). "Press Release: Pureos Bioventures Closes First Fund with USD 170 Million". St. Peter Port, Guernsey & Küsnacht....
- [10] Alentis Therapeutics AG. (7/29/20). "Press Release: Alentis Therapeutics Names Roberto Iacone CEO". Basel....
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