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Genedata AG. (2/2/18). "Press Release: Genedata Profiler Powers Major Breakthroughs in Early Prediction of Breast and Ovarian Cancer". Basel.

Organisations Organisation Genedata AG
  Group Genedata (Group)
  Organisation 2 EpiFemCare project (EU)
Products Product Genedata Profiler™ (s/w)
  Product 2 cancer test, early detection
Person Person Pfannes, Othmar (Genedata 200406 CEO)
     


Genedata plays pivotal role in discovery of epigenetic tumor markers to predict breast and ovarian cancer


Genedata, a leading provider of advanced software solutions for biopharmaceutical research and development (R&D), today outlined the pivotal role played by its scientists in groundbreaking work to improve the diagnosis and therapy of breast and ovarian cancer. As part of the EU-funded consortium EpiFemCare, Genedata scientists used Genedata Profiler, the leading enterprise software platform for omics-based profiling of patients in translational and clinical research, to process, manage, and analyze terabytes of data collected from patient blood samples in order to identify tumor DNA markers. These markers indicate the presence of cancer cells, even before any cancerous growth is otherwise detectable.

Due to leakage of normal DNA from white blood cells, tumor DNA fragments in patient serum samples become extremely diluted and hard to identify. As existing data analysis pipelines for DNA-methylation data have turned out to be inadequate for the task of DNA tumor identification, experts from the Genedata Data Science team invented new algorithms to successfully detect and quantify even minute quantities of tumor DNA with high sensitivity and specificity. These algorithms have been incorporated into workflows described here, and are now available to Genedata Profiler clients.

Based on this work, the EpiFemCare project generated highly significant results, including the discovery of a new serum DNA methylation marker, termed EFC#93, which can be used to diagnose potentially fatal breast cancer up to one year ahead of current methods. The consortium also demonstrated that DNA methylation patterns in a panel of markers can detect some ovarian cancers up to two years before diagnosis. These findings, published in the peer-reviewed journal Genome Medicine, are expected ultimately to facilitate personalized treatment of women afflicted with breast or ovarian cancer. See also a video abstract of the breast cancer study paper.

Commenting on publication of the breast cancer research results, Professor Martin Widschwendter, coordinator of the study, said: “For the first time, our study provides evidence that serum DNA methylation markers such as EFC#93 provide a highly specific indicator that could diagnose fatal breast cancers up to one year in advance of current diagnosis. This may enable individualized treatment, which could even begin in the absence of radiological evidence in the breast.”

Dr Othmar Pfannes, CEO of Genedata, stated: “I am excited about the success of the EpiFemCare project and very proud of the contributions of our Genedata team. This project exemplifies the value that the Genedata Data Science team, working with our software, can bring to complex and challenging fields such as liquid biopsy testing.”

Experts from Genedata offices in Basel, Switzerland and Munich, Germany worked in EpiFemCare with other scientists and physicians from University College London (UK), GATC Biotech (Germany), Ludwig-Maximilian University (Germany), and Charles University in the Czech Republic.


About Genedata

Genedata transforms data into intelligence with innovative software solutions and domain-specific consulting services that automate complex, large-scale experimental processes and enable organizations to maximize the ROI from their R&D. Founded in 1997, Genedata is headquartered in Switzerland and has offices in Germany, the UK, Japan, and the US.


Disclaimer

The statements in this press release that relate to future plans, events or performance are forward-looking statements that involve risks and uncertainties, including risks associated with uncertainties related to contract cancellations, developing risks, competitive factors, uncertainties pertaining to customer orders, demand for products and services, development of markets for the Company's products and services. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. The Company undertakes no obligation to release publicly the result of any revisions to these forward-looking statements that may be made to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.

All product and service names mentioned are the trademarks of their respective companies.

   
Record changed: 2018-02-11

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