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Domain Therapeutics S.A.. (12/4/18). "Press Release: Domain Therapeutics Signs a Multi-target Research Collaboration and License Agreement with Boehringer Ingelheim on G Protein-Coupled Receptors (GPCRs) for Central Nervous System Disorders". Strasbour
> Domain Therapeutics’ unique platform technologies will be used to identify novel treatment approaches for neuropsychiatric diseases
> Domain Therapeutics is eligible to receive upfront, milestone and royalty payments
Domain Therapeutics announces a multi-target drug discovery collaboration and licensing agreement with Boehringer Ingelheim on orphan G Protein-Coupled Receptors (GPCRs) in the Central Nervous System (CNS) disease area. The collaboration combines the expertise of Domain Therapeutics, a French and Canadian biopharmaceutical company, in the discovery of GPCR targeting drugs in CNS, oncology and immuno-oncology, with Boehringer Ingelheim’s expertise in the discovery and clinical development of therapeutics on multiple indications. Domain Therapeutics will use its proprietary platforms, DTect-All™ and bioSens-All™, which enable a comprehensive characterization of small molecule GPCR binders for the screening and characterization of potential lead compounds. In addition, Domain brings on board its extensive network of leading GPCR experts to provide additional knowledge and insight to the discovery phase (Prof Brigitte Kieffer (Douglas Institute – Montreal, Canada) and Prof Michel Bouvier (IRIC Institute - Montreal, Canada).
Domain will be eligible for an upfront payment, discovery, development and commercial milestone payments as well as royalties on sales. Financial details are not disclosed.
“We are excited to initiate the collaboration with Domain Therapeutics, a leading player in the GPCR space. This collaboration helps us to bolster our CNS research efforts,” says Dr Bernd Sommer, Global Head, CNS Diseases Research. “We have a valuable partner with complementary expertise and key technologies that allow us to accelerate research and development in this area of great unmet medical need.”
“With its focus on emerging science and breakthrough medicines, we are enthusiastic to be working with Boehringer Ingelheim,” says Pascal Neuville, CEO of Domain Therapeutics. “We believe that our approach and technologies will allow for the identification of new drug candidates against these challenging targets, and, coupled with Boehringer Ingelheim’s strength and expertise, their rapid advancement into the clinic.”
About G Protein-Coupled Receptors
GPCRs belong to the family of membrane receptors and constitute one of the main classes of therapeutic targets for many indications. The binding of a hormone or a specific ligand to a receptor’s binding site activates one or several pathways for intracellular signaling. This enables the cell to provide an adapted response to the change in its environment. The many drugs that target GPCRs represent about 40% of all treatments on the market, but only address 15% of GPCRs. Thus, GPCRs remain largely underexploited to date. Such receptors are widely expressed in the central nervous system where they play critical roles in regulating brain functions. A significant number of GPCRs are orphan receptors with no known ligand, making the corresponding drug discovery effort particularly challenging. Such complex targets are not addressable with conventional drug discovery approaches and require dedicated technologies.
About Domain Therapeutics
Domain Therapeutics is a biopharmaceutical company dedicated to the discovery and early development of new drug candidates targeting transmembrane receptors, in particular G ProteinCoupled Receptors (GPCRs), one of the most important classes of drug targets. Domain identifies and develops candidates (allosteric modulators and biased ligands) through its innovative approach and technologies. Domain has three revenue generating pillars to its innovative business model: 1) collaboration with pharma companies for the discovery of new molecules, 2) out-licensing of its bioSens-All™ technology and 3) creation of asset centric vehicles for the development of its internal pipeline of preclinical candidates for central nervous system disorders and cancer. These asset-centric companies attract investment for focused development and exit is through a trade sale at an appropriate inflection point. www.domaintherapeutics.com
Media contacts and analysts
Andrew Lloyd & Associates
Agnes Stephens | Juliette Dos Santos
agnes@ala.com | juliette@ala.com
Tel: +44 1273 675 100
@ALA_Group
Record changed: 2023-06-05 |
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- [1] Domain Therapeutics S.A.. (5/12/22). "Press Release: Domain Therapeutics Raises $42m Series A Financing to Accelerate Clinical Development of Its Best-in-Class and First-in-Class Immuno-oncology Programs". Strasbourg & Montréal, ON....
- [2] Domain Therapeutics S.A.. (1/13/20). "Press Release: Domain Therapeutics Secures €6 Million ($6.7M) Debt Financing". Strasbourg....
- [3] Domain Therapeutics S.A.. (9/11/19). "Press Release: Domain Therapeutics Invests in Ermium Therapeutics to Develop First-in-class CXCR4 Candidate for Autoimmune Diseases". Strasbourg....
- [4] Domain Therapeutics S.A.. (5/28/19). "Press Release: European Venture Capital Firm Seventure Partners Renews Its Support to Domain Therapeutics and Invests €3.5M ($3.9M) to Prepare the Next Growth Phase". Strasbourg....
- [5] Domain Therapeutics S.A.. (4/25/17). "Press Release: Pfizer Inc. and Domain Therapeutics Enter into a Collaboration Agreement on bioSensAll". Strasbourg & Montréal, ON....
- [6] Merck KGaA. (1/23/17). "Press Release: Merck Announces Research Collaboration with Domain Therapeutics in Immuno-Oncology [Not intended for UK- or US-based media]". Darmstadt....
- [7] Domain Therapeutics S.A.. (1/23/17). "Press Release: Domain Therapeutics and Merck Enter into a License and Collaboration Agreement for Development of Adenosine Receptor Antagonists in Immuno-oncology". Strasbourg....
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